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Implementing Outcomes-Based Managed Entry Agreements for Rare Disease Treatments: Nusinersen and Tisagenlecleucel

Artículos Científicos

Enthusiasm for the use of outcomes-based managed entry agreements (OBMEAs) to manage uncertainties apparent at the time of appraisal/pricing and reimbursement of new medicines has waned over the past decade, as challenges in establishment, implementation and re-appraisal have been identified. With the recent advent of innovative treatments for rare diseases that have uncertainties in the…

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Historical exposure to persistent organic pollutants and cardiovascular disease: A 15-year longitudinal analysis focused on pharmaceutical consumption in primary care

Despite restrictions on their production and use, most of the population is still exposed to Persistent Organic Pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs). These chemicals are thought to contribute to the aetiology of highly prevalent chronic conditions, such as cardiovascular diseases (CVDs), although current evidences are still controversial. Objectives To explore…

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Public health policies for the common interest: rethinking EU states’ incentives strategies when a pandemic reshuffles all interests

Artículos Científicos

The paper “Should governments buy the drug patents?” published 13 years ago in this same journal [1] reflected on aspects that have become relevant again, both for good and bad reasons. The last 60 years have seen huge advances in many of the scientific, technological, and managerial factors that raises the efficiency of commercial medicines research…

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Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study

Artículos Científicos

Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case–control study…

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Circulating tryptophan metabolites and risk of colon cancer: results from case-control and prospective cohort studies

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis, however, epidemiological studies investigating tryptophan metabolites in relation to colorectal cancer risk are limited. We studied associations of plasma tryptophan, serotonin, and kynurenine with colon cancer risk in two studies with cancer patients and controls, and in one prospective cohort: ColoCare Study (110 patients/153 controls),…

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Consideraciones de seguridad en la prescripción de medicamentos antiinflamatorios no esteroideos (AINEs), a través de una revisión de revisiones sistemáticas

Artículos Científicos

Los medicamentos antiinflamatorios no esteroideos (AINEs) se encuentran entre los medicamentos más consumidos mundialmente. Esto hace necesario realizar una síntesis amplia de la evidencia disponible sobre la prescripción segura y adecuada de AINEs en pacientes con enfermedad cardiovascular, enfermedad renal crónica, hipertensión, insuficiencia cardíaca o cirrosis hepática y en población general. Para ello se ha…

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Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

The role of chronic inflammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the inflammatory potential of the diet and risk of BC overall, according to menopausal status and tumour subtypes. Within the European Prospective Investigation into Cancer and…

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Jornada Suicidio 2021

Jornadas, Jornadas y eventos

Jornada Suicidio 2021 #NoestásSolo 2ª JORNADA VIRTUAL PREVENCIÓN DEL SUICIDIO 12 de noviembre de 2021 DIRIGIDO A Dirigido a profesionales sociosanitarios y grupos de intervención urgente (Bomberos, Policía, Emergencias Sanitarias 061, ..). Asociaciones y famliares. COORDINACIÓN José Luis Bimbela. DESCARGAR PROGRAMAVER JORNADA 2020 VER JORNADA SUICIDIO 2021 Sesión de la mañana – Escenarios – 1Bienvenida…