Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study

Background Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers. Methods We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI),…

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The…

Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC…

Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations

Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate…

Health-related quality of life in patients newly diagnosed with prostate cancer: CAPLIFE study

Purpose To analyse the Health-Related Quality of Life (HRQoL) at diagnosis of patients with prostate cancer (PCa) according to tumour extension and urinary symptomatology and to explore factors associated with HRQoL. Methods 408 Controls and 463 PCa cases were included. Eligibility criteria were a new diagnosis of PCa (cases), 40–80 years of age, and residence in…

Propuestas para la orientación comunitaria de la atención primaria: identificar agentes clave para la formación

Objetivo Identificar las fortalezas disponibles para la orientación comunitaria de la atención primaria de salud (APS) en el contexto de la evaluación del pilotaje de un programa formativo en salud comunitaria para especialistas internos residentes en Andalucía. Método Estudio cualitativo explicativo de diseño fenomenológico, en el que se analiza la opinión de las personas participantes,…

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and…

Prestación de la asistencia dental infantil y su registro en el Sistema de Información

Prestación de la asistencia dental infantil y su registro en el Sistema de Información Inscripción: ABIERTA Duración:  10 horas Plazas disponibles: sin límite Evaluación: Cuestionarios de autoevaluación Obtención de diplomaINSCRIBIRSE AL CURSOACCESO AL CURSOA quién va dirigido Dentistas de cabecera que participan en el Programa de Asistencia Dental Infantil de Andalucía. Objetivos El objetivo general…

Implantación del Documento de Consenso del Antibiograma para Atención Primaria adaptado al tipo de muestra en el SSPA

Implantación del Documento de Consenso del Antibiograma para Atención Primaria adaptado al tipo de muestra en el SSPA Inscripción: ABIERTA Duración:  2 horas Plazas disponibles: sin límite Evaluación: Cuestionarios de autoevaluación Obtención de diplomaINSCRIBIRSE AL CURSOACCESO AL CURSOA quién va dirigido • En Atención Primaria: Médicos de Familia, Pediatras, Enfermeras, Directores de Unidades de Gestión…