Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative…

Healthy Lifestyle and Risk of Cancer in the European Prospective Investigation Into Cancer and Nutrition Cohort Study

Abstract: It has been estimated that at least a third of the most common cancers are related to lifestyle and as such are preventable. Key modifiable lifestyle factors have been individually associated with cancer risk; however, less is known about the combined effects of these factors. This study generated a healthy lifestyle index score (HLIS)…

Effect of eccentric training on biomechanical properties of the Achilles tendon

Background: This demonstrated the effectiveness of eccentric exercise in the rehabilitation of Achilles tendinitis, on pain and function, but not known, the biomechanical changes that occur in the tendon, which can explain this evidence. Methods: A group of 17 healthy men, with 43.76 ± 8.03 years performed eccentric exercise training of plantiflexors with one leg and concentric…