Background Advanced Therapy Medicinal Products (ATMPs) developed under the Hospital Exemption (HE) offer innovative treatments for patients with unmet medical needs, but their pricing and reimbursement (P&R) remain fragmented and poorly understood. This paper examines the P&R landscape for HE-ATMPs developed by academic developers in Spain, based on the Spanish costing guideline and extends the…
Introducción La decisión clínica en unidades de cuidados intensivos en pandemia por COVID-19 ha sido escasamente estudiada. Los objetivos del estudio son determinar la variabilidad de las decisiones de intensivistas en Chile, analizar la asociación de la decisión clínica con ciertos factores contextuales (hora, ola pandémica, edad del paciente, información clínica disponible) y estimar la…
Background Pleural mesothelioma (PM) is a rare, asbestos-linked cancer with a long asymptomatic latency, delaying diagnosis and limiting treatment options. Identifying blood‐based biomarkers that signal disease before symptoms onset could improve surveillance of at‐risk individuals. Methods In our work, we conducted a prospective proteomic study of pre-diagnostic serum from 21 PM cases (< 5 years before…
Introduction As a consequence of major therapeutic advances that have transformed multiple myeloma (MM) into a manageable chronic condition, treatment sequencing has become highly complex. According to current practices, novel therapies are predominantly reserved for later disease stages, yet limited evidence suggests that this approach yields optimal long-term outcomes. Understanding the drivers of current practices…
Background Long-term benzodiazepine (BZD) use is associated with adverse clinical outcomes and increased healthcare utilization. Although deprescription programs aim to reduce these risks, the net economic impact of BZD discontinuation—particularly in terms of healthcare resource use—remains unclear. This study aimed to evaluate the cost-utility of BZD deprescription intervention in primary care, assessing its impact on…
Riesgo CardiovascularJornada de Prevención de Riesgo Cardiovascular 7 de abril de 2026 – Escuela Andaluza de Salud Pública Secretaría: jornadas.easp@juntadeandalucia.es Estrategia de Salud Cardiovascular ESCAV. PROGRAMAVER NOTICIAS PRENSA Y FOTOSVER JORNADA EN DIFERIDO
Background Metabolomics is a valuable tool for characterising biological mechanisms involved in cancer development, but produces complex datasets with intricate interdependencies. While linear dimension reduction techniques such as principal component analysis (PCA), have proven useful to summarise informative hidden patterns, biological evidence suggests metabolic relationships extend beyond linearity. Non-linear dimension reduction techniques, such as autoencoders…
Background: Although there is evidence that Fusobacterium spp. in colon tissue is associated with prognosis, less is known about the association between antibody response to antigens expressed by fusobacteria and colorectal cancer–specific mortality. Methods: Antibody responses to 11 Fusobacterium nucleatum (ATCC 25586) antigens were measured in prediagnostic blood for 471 incident colorectal cancer cases (median…
Background: Drug-facilitated sexual assaults (DFSAs) in youth partying contexts represent a growing public health concern, affecting approximately half of women and 1 in 4 men. These assaults often occur in environments where alcohol and other psychoactive substances are consumed, leading to impaired consent and increased vulnerability. At the same time, young people are increasingly exposed…
Background Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare changes over time in breast cancer incidence, by stage at diagnosis, and breast cancer mortality across countries…
