A data-driven framework for predicting PEG-defined MacroB12 in hypercobalaminemia
MacroB12 interference presents a significant challenge in the diagnosis of Vitamin B12 status, potentially masking true deficiency. To establish robust predictors and quantify the utility of pre-polyethene glycol (PEG) B12 levels, we conducted a retrospective analysis of 875 individuals with hypercobalaminemia (>1000 pg/mL), using multiple imputation to handle missing data. Multivariable regression modelling revealed that PEG-defined…











