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Factores contextuales y uso de heurísticos en atención por intensivistas a pacientes críticos durante la pandemia COVID-19: estudio cuasi-experimental con viñetas en Chile

Artículos Científicos

Introducción La decisión clínica en unidades de cuidados intensivos en pandemia por COVID-19 ha sido escasamente estudiada. Los objetivos del estudio son determinar la variabilidad de las decisiones de intensivistas en Chile, analizar la asociación de la decisión clínica con ciertos factores contextuales (hora, ola pandémica, edad del paciente, información clínica disponible) y estimar la…

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A proteomics approach to identify predictive blood biomarkers for pleural mesothelioma in prospective cohorts

Artículos Científicos, Cáncer

Background Pleural mesothelioma (PM) is a rare, asbestos-linked cancer with a long asymptomatic latency, delaying diagnosis and limiting treatment options. Identifying blood‐based biomarkers that signal disease before symptoms onset could improve surveillance of at‐risk individuals. Methods In our work, we conducted a prospective proteomic study of pre-diagnostic serum from 21 PM cases (< 5 years before…

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Policy approach to optimize multiple myeloma treatment sequencing practices

Artículos Científicos

Introduction As a consequence of major therapeutic advances that have transformed multiple myeloma (MM) into a manageable chronic condition, treatment sequencing has become highly complex. According to current practices, novel therapies are predominantly reserved for later disease stages, yet limited evidence suggests that this approach yields optimal long-term outcomes. Understanding the drivers of current practices…

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Cost-utility analysis of benzodiazepine deprescription in primary care: a cohort study

Artículos Científicos, Mujeres EASP

Background Long-term benzodiazepine (BZD) use is associated with adverse clinical outcomes and increased healthcare utilization. Although deprescription programs aim to reduce these risks, the net economic impact of BZD discontinuation—particularly in terms of healthcare resource use—remains unclear. This study aimed to evaluate the cost-utility of BZD deprescription intervention in primary care, assessing its impact on…

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Autoencoders reveal polyunsaturated fatty acids (PUFA)-Related metabolic signature linked to cancer risk

Artículos Científicos, Cáncer, Investigación

Background Metabolomics is a valuable tool for characterising biological mechanisms involved in cancer development, but produces complex datasets with intricate interdependencies. While linear dimension reduction techniques such as principal component analysis (PCA), have proven useful to summarise informative hidden patterns, biological evidence suggests metabolic relationships extend beyond linearity. Non-linear dimension reduction techniques, such as autoencoders…

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Antibody Responses to 11 Fusobacterium Proteins and Colorectal Cancer–Specific and Overall Survival in the EPIC Cohort

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background: Although there is evidence that Fusobacterium spp. in colon tissue is associated with prognosis, less is known about the association between antibody response to antigens expressed by fusobacteria and colorectal cancer–specific mortality. Methods: Antibody responses to 11 Fusobacterium nucleatum (ATCC 25586) antigens were measured in prediagnostic blood for 471 incident colorectal cancer cases (median…

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Drug-Facilitated Sexual Assault Pornography and Sexual Violence While Partying: Cross-Sectional Study

Artículos Científicos, Investigación, Mujeres EASP

Background: Drug-facilitated sexual assaults (DFSAs) in youth partying contexts represent a growing public health concern, affecting approximately half of women and 1 in 4 men. These assaults often occur in environments where alcohol and other psychoactive substances are consumed, leading to impaired consent and increased vulnerability. At the same time, young people are increasingly exposed…

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Breast cancer incidence, by stage at diagnosis, and mortality in 21 European countries in the era of mammography screening: an international population-based study

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare changes over time in breast cancer incidence, by stage at diagnosis, and breast cancer mortality across countries…

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Interactions between genetic predisposition to obesity, insulin resistance and type 2 diabetes risk, and food or beverage intake for incident type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC) InterAct case–cohort study

Cáncer, Investigación

Background Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested…