Serum levels of hsa‐miR‐16‐5p, ‐29a‐3p, ‐150‐5p, ‐155‐5p and ‐223‐3p and subsequent risk of chronic lymphocytic leukemia in the EPIC study
Chronic lymphocytic leukemia (CLL) is an incurable disease accounting for almost one‐third of leukemias in the Western world. Aberrant expression of microRNAs (miRNAs) is a well‐established characteristic of CLL, and the robust nature of miRNAs makes them eminently suitable liquid biopsy biomarkers. Using a nested case‐control study within the European Prospective Investigation into Cancer and…
Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort
Endometrial cancer (EC) incidence rates vary ~10‐fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low‐risk countries can…
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was…
Who does what the cardiologist recommends? Psychosocial markers of unhealthy behavior in coronary disease patients
Patients diagnosed with coronary heart disease should follow lifestyle recommendations that can reduce their cardiovascular risk (e.g., avoid smoking). However, some patients fail to follow these recommendations and engage in unhealthy behavior. With the aim to identify psychosocial factors that characterize patients at high risk of repeated cardiovascular events, we investigated the relationship between social…
Jornada Implantación Evidencias en Cuidados BPSOAndalucía
Bienvenida Institucional (1ª parte) Bienvenida Institucional (2ª parte) Programa de Implantación de buenas prácticas en Centros Comprometidos con la Excelencia en Cuidados Presentación del BPSO-Host Regional Andalucía Presentación de los proyectos de Candidatos a Centros Comprometidos con la Excelencia en Cuidados Transferencias de evidencias a la práctica clínica en centros del Sistema Sanitario Público de…
A general framework for classifying costing methods for economic evaluation of health care
According to the most traditional economic evaluation manuals, all “relevant” costs should be included in the economic analysis, taking into account factors such as the patient population, setting, location, year, perspective and time horizon. However, cost information may be designed for other purposes. Health care organisations may lack sophisticated accounting systems and consequently, health economists…