Trabajo nocturno por turnos y el riesgo de cáncer de mama y próstata: actualizando la evidencia a partir de estudios epidemiológicos

Resumen   Se ha formulado la hipótesis de que la disrupción circadiana está relacionada con un mayor riesgo de cáncer. Desde que la Agencia Internacional de Investigación sobre el Cáncer clasificó la disrupción circadiana asociada al trabajo por turnos como “probablemente carcinógeno para los humanos” (Grupo 2A) se han llevado a cabo numerosos estudios para…

Projecting Pharmaceutical Expenditure in EU5 to 2021: Adjusting for the Impact of Discounts and Rebates

Background Within (European) healthcare systems, the predominant goal for pharmaceutical expenditure is cost containment. This is due to a general belief among healthcare policy makers that pharmaceutical expenditure—driven by high prices—will be unsustainable unless further reforms are enacted. Objective The aim of this paper is to provide more realistic expectations of pharmaceutical expenditure for all…

Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study

Background & Aims Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most studies have been of insufficient size to identify heterogeneous associations with precision. Methods In the European Prospective Investigation into Cancer and Nutrition study, we…

Thyroid Cancer Epidemiology in South Spain: a population-based time trend study

Purpose Thyroid cancer (TC) is the most common malignant disease of the endocrine system. The aim of this study was to analyze incidence and mortality trends of TC (C73 according to ICD-O-3) in Granada (Southern Spain) during the period 1985–2013, by sex, age, and histological type. Methods This is a population-based cross-sectional study. Incidence data…