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Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. Methods We investigated associations of genetic susceptibility to type 2 diabetes (T2D), 8 T2D mechanistic clusters, type 1 diabetes (T1D), and maturity-onset diabetes of the young (MODY) with PDAC risk. We…

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Cost-Effectiveness of Sacituzumab Govitecan and Physician’s Choice of Treatment in Patients with Metastatic Triple Negative Breast Cancer in Spain

Artículos Científicos, Investigación

Background and Objectives Patients with metastatic triple-negative breast cancer (mTNBC) have poor prognosis and survival outcomes. Sacituzumab govitecan (SG) has shown significant survival benefits, but its cost-effectiveness still needs evaluation. The present study aimed to evaluate the cost-effectiveness of SG versus physician’s choice of treatment in patients with mTNBC in the context of the Spanish…

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Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: PSA is central to referrals for prostate biopsy but has low specificity for aggressive prostate cancer. This study evaluates the 4Kscore (OPKO Diagnostics) versus total PSA in predicting short- and long-term risks of aggressive prostate cancer. Methods: Baseline blood samples from 1,658 men diagnosed with prostate cancer (median diagnosis time = 8.6 years) and…

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Skin melanoma survival is improving in Europe but regional differences persist: Results of the EUROCARE-6 study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background The aim of this study was to update previous EUROCARE survival estimates for skin melanoma (SM) monitoring trends and survival differences between European regions. Methods 1-year, 5-year, and 5-year/1-year conditional age-standardised relative survival (ASRS) and geographical comparisons were estimated on 280,498 patients participating in the EUROCARE-6 project (>=15 years old) with invasive SM (diagnosed…

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Lifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background The risk of breast cancer has been associated with various lifestyle factors, yet the evidence regarding how lifestyle modifications affect this risk remains limited. This study examines the relationship between changes in the Healthy Lifestyle Index (HLI) and postmenopausal breast cancer risk in women participating in the European Prospective Investigation into Cancer (EPIC). Methods…

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Addressing common biases in the evaluation of lifetime alcohol consumption patterns and dementia risk: the EPIC-Spain dementia cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: Alcohol consumption has been described to exhibit a J-shaped relationship with dementia risk, but previous observations may be partly biased due to “sick-quitters” and competing risks of death. Objective: To examine the association between baseline and lifetime alcohol consumption and the risk of dementia and subtypes in a large Mediterranean cohort, accounting for lifetime…

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Risk perception, attitudes, and quality of life in a multicomponent benzodiazepine deprescription strategy

Artículos Científicos, Investigación

Background Multicomponent strategies can reduce benzodiazepine (BZD) use. BenzoStopJuntos (Spanish for “Stop Benzos Together”), a multidisciplinary deprescribing programme of the Andalusian Health Service, supports patients to taper/stop BZD through education, behavioral support, and non-pharmacological alternatives. We evaluated whether early changes (6 months) in risk perception and attitudes—and secondarily, quality of life—were associated with long-term discontinuation of…

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Breast Cancer Screening Rates Among Patients With Severe Mental Disorders (Schizophrenia, Bipolar Disorder, and Major Depressive Disorder). Systematic Literature Review and Meta-Analysis

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Introduction Women with severe mental disorders (SMD) experience premature mortality, with disparities in healthcare access and quality contributing to this trend. This study aimed to analyze breast cancer screening rates in women with schizophrenia, major depressive disorder, and bipolar disorder, compared to women without SMD. Methods A systematic review and meta-analysis were conducted using PubMed,…

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Global variation in patterns of care and time to initial treatment for breast, cervical, and ovarian cancer from 2015 to 2018 (VENUSCANCER): a secondary analysis of individual records for 275 792 women from 103 population-based cancer registries in 39 countries and territories

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Cancers of the breast, cervix, and ovary are a major public health problem worldwide. Evaluating the consistency with clinical guidelines for treatment by use of individual high-resolution data from population-based cancer registries is a powerful tool to help interpretation of global inequalities in cancer survival. The VENUSCANCER project aims to assess the worldwide variation…

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Understanding and reframing clinical errors through just culture: protocol for the DECIDE mixed-methods study in Spanish healthcare and community contexts

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Introduction Patient safety culture plays a crucial role in reducing clinical errors. By improving healthcare professionals’ and patients’ understanding of human fallibility and error attribution, patient care can be enhanced, fostering greater engagement from both groups. A Just Culture approach, which balances accountability and learning from errors, is a key factor in fostering this safety…