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Food Processing and Risk of Crohn’s Disease and Ulcerative Colitis: A European Prospective Cohort Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background & Aims Industrial foods have been associated with increased risks of several chronic conditions. We investigated the relationship between the degree of food processing and risks of Crohn’s disease (CD) and ulcerative colitis (UC) in the European Prospective Investigation into Cancer and Nutrition cohort. Methods Analyses included 413,590 participants (68.6% women; mean baseline age,…

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Cardiorespiratory Fitness and Bone Turnover Markers in Adults With Metabolic Syndrome: The Mediator Role of Inflammation

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults…

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The patient, diagnostic, and treatment intervals in adult patients with cancer from high- and lower-income countries: A systematic review and meta-analysis

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Longer time intervals to diagnosis and treatment are associated with worse survival for various types of cancer. The patient, diagnostic, and treatment intervals are considered core indicators for early diagnosis and treatment. This review estimated the median duration of these intervals for various types of cancer and compared it across high- and lower-income countries.…

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Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer, Investigación

Background Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods We analysed targeted metabolomics data available for 5828 matched case-control pairs…

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Incident Cardiovascular Diseases Among Survivors of High-Risk Stage II–III Colorectal Cancer: A Cluster-Wide Cohort Study

Artículos Científicos, Cáncer, Investigación

Background: The incidence and survival of colorectal cancer (CRC) are increasing. There is an increasing number of long-term survivors, many of whom are elderly and have comorbidities. We conducted a population-based study in Hong Kong to assess the long-term cardiovascular disease (CVD) incidence associated with adjuvant fluoropyrimidine-based chemotherapy among CRC survivors. Patients and Methods: Using…

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The cost-effectiveness of a uniform versus age-based threshold for one-off screening for prevention of cardiovascular disease

Investigación, Mujeres EASP

The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform” or “age-adjusted”) from the Spanish NHS perspective. The age-adjusted…

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Changes in lifestyle and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Introduction: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multi-country European cohort. Methods: We used baseline and follow-up questionnaire data from the EPIC cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking…

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La historia se repite: una ética para dos pandemias

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

La irrupción del virus de la inmunodeficiencia humana (VIH) en la década de los 80 trajo consigo conflictos éticos que supusieron un desafío para la Bioética. Surgieron, entre otros, problemas de confidencialidad, estigmatización, justicia, deber de asistencia y de investigación. Si hasta entonces la reflexión bioética había estado centrada en los conflictos protagonizados por el…