High-dose versus standard-dose influenza vaccine for immunocompromised patients: A systematic review and meta-analysis of randomised clinical trials

Background Immunocompromised patients present a higher risk of severe influenza disease and respond worse to vaccination. Objective We aimed to assess immunogenicity and safety of high-dose vs. standard-dose influenza vaccine in immunocompromised patients. Data source A search was conducted in Medline, Web of Science, Scopus and ClinicalTrials.gov from inception to March 2024 with no other…

Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?

Background Colon cancer is strongly influenced by lifestyle factors. Sociodemographic factors like sex and socioeconomic position (SEP) might modulate the relationship between lifestyle and colon cancer risk. Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer. Methods Lifestyle and untargeted metabolomic data were available from a nested case–control study within the European…

Revisión sistemática sobre el uso de peces para el control vectorial de las enfermedades transmitidas por mosquitos

FUNDAMENTOS // Se estima que un 80% de la población mundial está en riesgo de contraer una enfermedad de transmisión vectorial, siendo los mosquitos los responsables de una mayor carga de enfermedad. Dado que el control biológico es una opción más natural que otras intervenciones disponibles y que el uso de peces está muy extendido,…

Metabolic profile of biodiverse diets in a healthy European cohort

Background There is increasing evidence that diets characterized by food biodiversity could contribute to health outcomes. Greater dietary species diversity has been linked to reduced gastrointestinal cancer risk and all-cause mortality. However, mechanistic pathways supporting the association between food biodiversity and health are just beginning to be explored. Aim To characterize the metabolic profile associated…

Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies

Background Dietary guidelines recommend replacing saturated fatty acid with unsaturated fats, particularly polyunsaturated fatty acids. Cohort studies do not suggest a clear benefit of higher intake of polyunsaturated fatty acids but, in contrast, higher circulating linoleic acid (LA) levels—reflective of dietary LA intake, are associated with a reduced risk of type 2 diabetes. However, genetic…

Relationship Between Health-Related Behaviors and Family Quality of Life in Children with Autism Spectrum Disorder

Improving family quality of life (FQoL) of families of children with autism spectrum disorder (ASD) is a key priority in clinical research and practice. Previous studies have suggested that certain health-related behaviors in children with ASD, such as sleep or physical activity, may affect FQoL. However, the relative and independent effects of different health-related behaviors…

Propuesta de metodología cualitativa para la valoración externa de un proyecto basado en el desarrollo de activos comunitarios

Antecedentes: las acciones de promoción de la salud permiten abordar la injusticia de vivir en lugares no suficientemente dignos para ser habitados. Sin embargo, existen pocas metodologías que describan cómo realizar una evaluación externa en intervenciones de promoción de la salud desde una perspectiva de regeneración comunitaria en estos contextos. Objetivo: presentar un proceso de…

Impact of Pharmacogenetics on High-Dose Methotrexate Toxicity in Pediatric Oncology

Background: Childhood cancers represent a heterogeneous group of malignancies and remain one of the leading causes of mortality among children under 14 years of age, ranking second only to accidental injuries, and fourth among individuals aged 15 to 19 years. Despite notable improvements in cure rates, a substantial proportion of patients experience acute or long-term…

Seminario «Fiebre del Nilo Occidental»

SEMINARIO ONLINE:Fiebre del Nilo Occidental: sospecha diagnóstica, gestión de casos y actuaciones de salud pública. 26 de junio – 9:00-11:00 horas   Dirigido a: preferentemente a profesionales de la medicina, enfermería y urgencias de Atención Primaria y hospitalaria, tanto del ámbito público como privado. Red de vigilancia en salud pública, enfermería gestora de casos, escolar,…